Van Seenus finally rose to become an A-list model after working with
Mario Testino in 1995. In 1996, Van Seenus got her first fashion magazine cover by landing the cover of W alongside Amy Wesson.
Throughout her career, Van Seenus has been featured in advertising campaigns including Prada, Versace, Jil Sander, Chanel, Kenzo, Missoni and so on. She has also appeared on the covers of fashion magazines, such as Vogue Italia, i-D and Dazed & Confused.