Filipino actress Mendiola was born in the United Arab Emirates where her father used to work.She is the second of three siblings, of Filipino parents. She was three years old when her mother moved and brought her and her elder sister, Pamela to the Philippines. Her mother left her father due to his infidelity. Her younger sister, Megan was born in the Mexico when her parents reconciled but then separated again because of unknown reasons. She remains in contact with her father, who now works overseas as a marine anthropologist.Mendiola studied college in Far Eastern Universi
Jessy Mendiola was one of the 18 new talents launched by ABS-CBN under Star Magic Batch 15. She, along with Megan Young, Alfonso Martinez, Carlo Guevarra and her Star Magic batchmates, joined the cast of Star Magic Presents: Abt Ur Luv when it was revamped to Abt Ur Luv Ur Lyf 2 in 2007. She had a minor role in Sineserye Presents: Natutulog Ba Ang Diyos?
In 2008, she was cast as Chappy Girl in the TV series Volta, which was adapted from the Star Cinema film of the same name.